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The combination ensures both wanting and physical responsiveness are addressed

The percentage of IPC and geko devices in place and working correctly increased to 75.0% (n = 36, p 0.01), respectively following an intervention

Abstract Parkinsons disease (PD) is a common degenerative disease of the central nervous system with a variety of non-motor symptoms, in addition to the typical motor symptoms, which seriously affect the physical and mental health of patients, as well as their quality of life

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Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey