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An experiment using human peripheral blood macrophages (M) showed that the intracellular GSH content was dose-dependently increased by treatment of M with cystine, and was increased further by the addition of glutamate (Rimaniol et al

(2) Numerous immunoinflammatory abnormalities are also seen in people with ME/CFS indicating an activated but dysregulated immune system, including high levels of serum neopterin [13, 95], which is a surrogate marker for increased interferon (IFN) levels [114]