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These findings suggest that DUSP12 protects cardiomyocytes from oxidative stress and apoptosis by inhibiting ASK1-JNK/p38 signaling, leading to the suppression of diabetic cardiomyopathy pathogenesis

Oxidative stress has also been reported as a major factor in the formation of uterine fibroid 48, 49 , indicating that these findings concur with previous investigations 50, 51

doi: 10.1016/j.pbi.2015.11.009 107 SchmidtR.KunkowskaA

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Genetic testing for classical-like EDS (clEDS) was negative in the three families (families 4, 6, and 7) without a clear autosomal dominant history and not performed in the others