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Laurell and Eriksson observed in 1963 that individuals with a hereditary deficiency of the serum protein alpha-1 antitrypsin, which inhibits a number of serine proteinases such as neutrophil elastase, are at increased risk of developing emphysema 62

Furthermore, fresh mushrooms have a significant moisture content ranging from 85 to 95% and a rapid respiration rate (640.8 mg kg 1 h 1 ) at 10C for Lentinus edodes and (200 to 500 mg kg 1 h 1 ) for Agaricus bisporus which can encourage microbial growth and enzymatic browning, thus accelerating the aging process (38)

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This variability can cause repeated episodes of nerve ischemia and reperfusion, leading to further oxidative damage and inflammatory responses

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