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Elsom R, Sanderson P, Hesketh JE, Jackson MJ, Fairweather-Tait SJ, kesson B et al (2006) Functional markers of selenium status: UK Food Standards Agency workshop report

For example, berberine may accumulate to higher levels in children due to immature CYP3A and P-glycoprotein activity, posing risk of bradycardia or hypotension