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Even in that context, guardrails matter: begin below target dose, titrate gradually, define stop/go criteria, and monitor behavior and sleep (e.g., ABC-I, brief sleep logs)

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7 dropped out due to side effects or loss to follow-up

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SS-31 10mg Vial Best for: Short-term protocols (2-4 weeks) or testing tolerance Reconstitution: 1.0 mL bacteriostatic water 10 mg/mL concentration Dosing at 10 mg/mL: 1 unit = 0.01 mL = 100 mcg 10 mg dose: 100 units (1.0 mL) Vials needed for 8 weeks @ 10mg/day: 50 vials SS-31 30mg Vial Best for: Standard 8-12 week protocols Reconstitution: 3.0 mL bacteriostatic water ~10 mg/mL concentration Dosing at 10 mg/mL: 1 unit = 0.01 mL = 100 mcg 10 mg dose: 100 units (1.0 mL) Vials needed for 8 weeks @ 10mg/day: 17 vials SS-31 50mg Vial Best for: Extended protocols or costeffective bulk research Reconstitution: 3.0 mL bacteriostatic water ~16.67 mg/mL concentration Dosing at 16.67 mg/mL: 1 unit = 0.01 mL 167 mcg 10 mg dose: 60 units (0.60 mL) Vials needed for 8 weeks @ 10mg/day: 10 vials Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing across all vial sizes Standard / Gradual Approach Frequency: Inject once daily subcutaneously at a consistent time

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