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Because probiotics stay in the colon only temporarily, regular consumption is necessary to maintain their populations in the colon

Why N-Acetylcysteine (NAC) Supplementation Might be a Better Option N-Acetylcysteine (NAC) is another form of cysteine that is considered less toxic, less susceptible to oxidation (and dimerization) and is more soluble in water, making it a better source of cysteine than parenteral administration of cysteine itself, according to Atkuri et al

Apr-Jun 2013;80(2):112-119

For translational application, the development of efficient and safe in vivo delivery vectors for the central nervous system, such as engineered AAVs, is a paramount next step

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Dosage may be adjusted appropriately to achieve desired drug levels, locally or systemically