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The animals were rated daily for Parkinsonian symptoms and dyskinesia using a PD clinical rating scale optimized for macaques 39,45,73 and a dyskinesia disability scale 74

Excitotoxicity may occur when, for instance, extracellular glutamate accumulates due to impaired uptake by astrocytes or excessive synaptic release

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Additionally, reduced expression of glial fibrillary acidic protein (GFAP) and lonized calcium-binding adapter molecule 1 (Iba-1) in glial cells was observed, indicating decreased inflammatory responses