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Genome-wide profiling of chromosomal aberrations in renal cell carcinoma using high-density single nucleotide polymorphism arrays

In addition, experiments were conducted to examine the levels of 8-oxoG in the cochleae of SAMP8 mice, a product of oxidative damage to guanine, which leads to telomere fragility, localized DNA damage response (DDR) signaling, and the repair of mitotic DNA repair synthesis (MiDAS) at telomeres, which in turn disrupts the normal cell division cycle without shortening the telomeres