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Introduction Asthma, a chronic inflammatory disease of the lung, affects up to 300 million people worldwide and remains a major cause of morbidity and mortality ( Despite advances in understanding the cellular drivers of asthma, several fundamental features of the disease remain poorly explained

This mechanism constructs a pathological intracellular positive feedback loop, forcing macrophages to maintain a high-glycolysis, high-inflammation metabolic state (Warburg effect), which in turn leads to the massive release of inflammatory factors and exacerbates lung tissue injury

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Growth hormone secretion declines naturally with age a process sometimes called somatopause

It has been observed that the interference in these pathways in complex ways has the greatest impact on disease development [12], apoptosis, cytokine production and inflammatory responses, and proteasome dysfunction

[DOI] [PubMed] [Google Scholar] 31.Yichong Z et al