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The ubiquitin-proteasome-mediated proteolytic system regulates the expression and activity of various proteins involved in cellular processes such as the cell cycle, proliferation, and apoptosis [44]

However, AEOL series has shown to have better stability (are excreted unchanged in the urine) and oral bioavailability compared to the EUK series, which can suffer from toxicity and instability under certain conditions (Liang et al., 2007

After treatment with arsenic trioxide (7 M) for 24 h, MT3 expression increased

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The toxicological profile of this brand-new soluble rapamycin derivative in animals was good