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Nevertheless, if we compare the internal states corresponding to Nrf2Keap1 complexes (Fig 3D), the dissociation model predicts an immediate decrease in the complex upon exposure to DEM followed by a sharp increase in complex formation, while the hinge-latch model predicts a prolonged increase in the complex that starts immediately upon oxidative stress

Despite these advances, the exact antiviral mechanisms of many ferroptosis regulators remain inadequately understood and require further study

Doglioni C, Ravaglia C, Chilosi M, Rossi G, Dubini A, Pedica F, et al

Complex systems are now recognized as demonstrating emergent behavior, with functions arising from the totality of system interactions, which are often nonlinear and stochastic

This will ultimately provide a rational basis for clinical practice

According to estimates by the Centers for Disease Control and Prevention (CDC), approximately 1.35 million cases of NTS infection occur annually in the United States, which result in 26,500 hospitalizations, 420 deaths, and direct health care costs estimated at $400 million (Kuehn, 2019)