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Nat Rev Gastroenterol Hepatol 6(5):306314

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

However, adjuvant chemotherapy conferred no survival benefit in localized or advanced disease, highlighting stage and histology as key outcomes

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doi: 10.1158/0008-5472.CAN-18-1010 10 AlhalabiOZhuYHamzaAQiaoWLinYWangRMet al

383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)