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Testing was conducted using the remaining subgroup, and ROC curves using the pROC 87 package were determined to obtain AUCs

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Since the protective action of melatonin was accompanied by increased mucosal blood flow and could be attenuated by pretreatment with COX or NO inhibitors such as indomethacin or L-NAA, respectively, and by pretreatment with capsaicin in neurotoxic dose (125 mg/kg) to inactivate the sensory nerves (45), we propose that melatonin protects esophageal mucosa by increasing the mucosal blood flow due to the enhancement of prostaglandin, NO and CGRP release in the mucosa

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Tyrosinase is blocked by tyrosinase inhibitors (melanin inhibitors) and by carefully protecting your skin against sun damage