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During the oxidation step of AA by COX and LOX, lipid-derived electrophiles may be produced incidentally and play critical roles in the development of cardiovascular disorders, including atherosclerosis, hypertension, and myocardial infarction (MI)

Disruption of this balance can lead to oxidative stress, a condition characterized by excess reactive oxygen species (ROS) that can damage lipids, proteins, and DNA

Serum Biochemical Assays Serum ALT and aspartate aminotransferase (AST) levels were measured using ALT and AST assay kits (Lot number 20180628, Nanjing Jiancheng Bioengineering Institute, Nanjing, China)

Naccache, S

2) Phase 2 T2D + metformin cagrilintide 1.2 + semaglutide 1.2 = 15.6% weight, 2.2% HbA1c (vs semaglutide 2.4 mono: 5.1% / 1.8%)

Xiao M, Zhang Y, Zhang X, Zhang G, Jin C, Yang J, et al