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Further, many reported small-molecule inhibitors target several metabolic enzymes with similar structures, for example, EGCG targets both NADPH-dependent FASN and NADP + -dependent GDH

10.1016/j.cbi.2019.108936 38 TianY.LuJ.HaoX

Besides conventional drug discovery approaches, cost-effective ways to accelerate identification of novel antimalarial strategies have included (i) combination therapy, by joining two or more known drugs, (ii) covalent bitherapy, by conjugating different pharmacophores, (iii) repurposing of drugs with other therapeutic indications, and (v) rescuing of known antimalarial scaffolds