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The downstream effects accumulate well before anyone would describe them as frank disease

Jia HM, Huang LF, Zheng Y, Li WX (2017) Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis

The TTDS builds on the longstanding engineering notion of treatment trains but extends it into a design space where modular units are mapped, benchmarked, and optimized in terms of recovery synergies and trade-offs 20

Different Forms of Vitamin B12 It might surprise you to learn that not all vitamin B12 is created equal

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