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It acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD + to remove acetyl groups from proteins

Medlock L, Sekiguchi K, Hong S, Dura-Bernal S, Lytton WW, Prescott SA (2022) Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain

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27,28,29 But it was not until the discovery of signaling mediators small (Sma) in Caenorhabditis elegans and mothers against decapentaplegic (Mad) in Drosophila melanogaster that the homologous small mothers against decapentaplegic (SMAD) proteins were identified as the canonical signal transducers of TGF- signaling in humans in 1996

A., Hoy, D., Ashrafi-Asgarabad, A., Sepidarkish, M., Almasi-Hashiani, A., Collins, G., Kaufman, J., Qorbani, M., Moradi-Lakeh, M., Woolf, A