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Research by Ershov et al

2 New England Journal of Medicine REDEFINE 2Davies M et al

The published research base, predominantly preclinical with growing clinical extension, identifies several mechanisms of action

CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life