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PC9ER and H1975 cells displayed significant resistance to erlotinib as compared with their sensitive counterparts (Supplementary Figure S1A)

Proteins were eluted (with 10 mM TCEP in 50 mM HEPES, pH 7.7) after washing, and then alkylated with 10 mM iodoacetamide (IAM)

Exploring FAF1 function could therefore provide new avenues for triggering ferroptosis and enhancing cancer therapy (Fig

Regulated portals of entry into the cell

10.1152/ajprenal.00462.2018 116 OtsukaY.FurihataT.NakagawaK.OhnoY.ReienY.OuchiM.et al (2019)

During oxidative stress, KEAP1 undergoes conformational changes that disrupt this interaction, resulting in the stabilization of NRF2