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Despite these promising findings, more extensive clinical trials are needed to investigate long-term efficacy and potential therapeutic applications (1)

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Maintaining hydration during GI flare-ups is the main prevention

Insulin-like growth factor long arginine 3 (IGF-1 LR3), is a widely used synthetic analog of IGF-1 with an arginine replacing glutamic acid at position 3 (arginine 3, R3), and an additional 13 amino acids at its N-terminus (long, L)

32,33 A strength of this analysis is that it included both bDMARD-nave and TNFi-IR patients, showing the relevance to patients across the 2 PsA populations

Temsirolimus is unlikely to reach the clinic because it has devastating side effects even with acute administration, having its use likely restricted to the oncology field [270]