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Due to their high metabolic demands, the RPE and other photoreceptors have an abundance of mitochondria (Figure 3) ( 5 Age-related retinal degeneration and its relation to phase separation The cells of all tested living organisms depend upon phase separation, a spontaneous thermodynamic process enabling fluid, reversible cellular compartmentalization, to rapidly organize/reorganize functions/reactions in response to the fluctuating cellular environment ( -helical rod domain of vimentin induces phase separation of reversible membrane-less condensates in its N-terminal low complexity domain (Figure 5)

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