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Zhang Y, Ma R, Deng Q, Wang W, Cao C, Yu C, et al

In addition, breast cancer cells divert excess PUFAs into TAGs and store them in LDs, effectively buffering oxidative stress from an excess of lipids and sustaining cell viability under the pressure of hypoxia and ferroptosis 105,106

Its stored in the liver , so symptoms of deficiency can creep in slowly but cause profound fatigue, memory issues, numbness, and low mood

Amino acid metabolism in drug resistance With increased demand for nutrients during chemotherapy, cancer cells have been shown to upregulate L-type amino acid transporter 1 (also known as SLC7A5), which helps in the transportation of branched chain amino acids, such as leucine, isoleucine, valine, and bulky amino acids such as phenylalanine, tryptophan, tyrosine, methionine, glutamine, asparagine, and histidine, and is associated with TNBC [31, 122, 123]

One notable example is the CBR3 V244M variant a single nucleotide polymorphism in the carbonyl reductase 3 genewhich has been associated with increased conversion of doxorubicin to its cardiotoxic metabolite, doxorubicinol

In conclusion, SAC exerts antioxidant and anti-ferroptotic effects by modulating the Keap1/Nrf2/GPX4 signaling axis