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These platforms improve water solubility and cell permeability, optimize the pharmacokinetic characteristics of PROTAC, and promote selective localization in tumor tissue through passive or active targeting strategies, thus significantly enhancing treatment selectivity and treatment window [41,42,43,44]

8-OHdG can mispair with adenine during DNA replication, leading to G to T transversions

doi:10.1016/S0021-9673(98)00304-5 Amistadi MK, Hall JK, Bogus ER, Mumma RO (1997) Comparison of gas chromatography and immunoassay methods for the detection of atrazine in water and soil