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M., Campion, J., Milagro, F

The molecule's central role in cellular function has made it an invaluable target for research into aging mechanisms, metabolic disorders, neurodegeneration, and research interventions aimed at promoting healthy longevity and optimal cellular function

The evolution of aerobic respiration by mitochondria increased cellular production of superoxide, resulting in an increased reliance upon SOD1

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According to Shuja et al 11 study, risk factors for melasma other than GSH, there was also a decrease in levels of other antioxidants such as superoxide dismutase (SOD), catalase, vitamin E, and vitamin C which were statistically significant in melasma subjects compared to controls

However, even then, they are not usually toxic