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Serotonin syndrome typically presents with the triad of altered mental status, autonomic hyperarousal, and neuromuscular hyperactivity (hyperreflexia, clonus, tremor), predominantly affecting the lower extremities

Creatine also stimulates muscle protein synthesis through the Akt/mTOR pathway, supporting muscle growth beyond just energy production 2

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The major efficacy outcome measure was overall survival and additional efficacy outcome measures were time to disease progression, overall response rate, and response duration