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Drugs such as losartan can reduce levels of endothelin-1 and other serum inflammatory markers, thereby alleviating endothelial dysfunction

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In previous studies, TMAO, often used as a key metabolite in the study of microbial metabolome alterations in cardiovascular disease, has been shown to directly stimulate platelets by enhancing intracellular calcium release, among other pathways, causing platelet hyperreactivity, thereby increasing the risk of thrombus formation (50)

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10.1007/s10863-008-9155-9 J

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