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This proved to be effective in counteracting signs of chemotoxicity and, excitingly, was able to restore certain healthspan features in models for fast and natural aging, e.g

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Smad3 is activated by the TGF- signaling pathway, Stat5 responds to signals from IL-2R, TCR, and TGF- signaling pathway, while c-Rel activation occurs via TCR signaling pathway [159]