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Targeting key regulators in glutamine metabolism, such as glutaminases and glutamine transporters, prompts the discovery of druggable targets and promising anti-cancer drug candidates (Fig

Similar content being viewed by others Introduction Liver cancer, primarily HCC, is among the most challenging tumors to treat, ranking sixth globally in incidence and third in cancer-related deaths

312,316,317 Notably, the nucleic acid molecules in these conjugates are directly exposed to serum

Kobe J Med Sci (2018) 64(3):E10714

10.1055/s-0028-1088314 [DOI] [PubMed] [Google Scholar] Seelinger G., Merfort I., Wlfle U., Schempp C

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019