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ADO leads to tumor growth and skews the immune cells toward an immunosuppressive phenotype ( Figure 2 Adenosinergic pathways identified on different cell populations ( ADO is produced from the catabolism of mono- and di-nucleotides of adenine (ATP, NAD + and cAMP) (Figure 1)

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"We look forward to working with the FDA to complete this rolling submission and support their review, with the goal of securing full regulatory approval of the vaccine in the coming months." Shares of Pfizer were down nearly 1% in premarket trading Friday, while BioNTech's stock was down more than 1%

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