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In contrast, TRPM8 activation by linalool produces anti-angiogenic effects through inhibition of beta 1 integrin/focal adhesion kinase (FAK) signaling (Becker et al., 2021), which could be of great relevance to attenuating DR implications

Cyclization of 1) Preparation of cyclization reagent: dissolving iodine per gram in 30-40mL ethanol 2) Preparation of Vc reagent: dissolving Vc per gram in 20-30mL of purified water 3) Cyclization: the linear crude peptide was dissolved in 20% acetonitrile aqueous solution (1g of crude linear peptide in 100mL of 50% acetonitrile aqueous solution), and the linear peptide was dissolved and diluted to 1g/L with purified water

However, significant degradation can occur without any visible changes