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The number of these abnormal cells should not necessarily be considered an indicator of severity, but increased numbers of abnormal cells and polychromasia (or nucleated red cells) often occur during sickle crises

NicholsonJKHolmesEKinrossJBurcelinRGibsonGJiaWet al

Starting from the 1940s, microorganisms have played a significant role in uncovering important sources of various natural products used in the agrochemical, cosmetic, pharmaceutical, and food industries (Gakuubi et al., 2022)

doi: 10.1186/s12876-021-01977-1 27 JuntarachotNSunpaweravongSKaewdechAWongsuwanlertMRuangsriPPahumuntoNet al

I propose that all individual predispositions leading to self-sustained vicious circles constitute building blocks that can self-assemble in many possible ways, to give rise to both core and diverse features of PAIS