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Indeed, the high glucose demand of cancer cells induces a general adaptation of tissues, in particular skeletal muscle and liver, to finally increase glucose production

159 The notable abnormalities in host metabolism diminish nutrient and oxygen availability within the TME and lead to the accumulation of metabolic byproducts, which undoubtedly pose additional threats to cellular health and function

The resulting outer shell of amphipathic lipids and proteins solubilizes the hydrophobic lipid core in the aqueous environment

However, extremely high doses (over 2,000 mg per day) can sometimes cause digestive upset

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