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The significant increase in plasma vitamin B6 in many children with autism spectrum disorders [73, 76, 87, 92, 93] could potentially reflect diminished cellular uptake or inefficiency of cells to retain or store B6

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To gain insights into the underlying mechanisms of iron-induced oxidative stress, we examined the expression of oxidative stress markers, specifically nuclear factor erythroid 2-related factor 2 (Nrf-2) (Figures 4E, F) and heme oxygenase-1 (HMOX-1) (Figures 4G, H)

The antioxidant effects of GPx1 are achieved by the direct reduction of hydrogen peroxide and lipid hydroperoxides [13]

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