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Autophagy in endometriosis can be triggered by a number of factors such as oxidative stress, hypoxia, female hormones and specific signaling pathways (Fig

Though RNRs are highly diverse, their catalytic activity requires peptides harboring a free radical, redox-active thiols, and proteins of the thioredoxin family, and, therefore they are directly influenced by cell redox environment

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GSH is the most prominent antioxidant in RPE cells and is present at high concentration in retina and RPE 13,14

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