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that looked at oral versus intramuscular administration: In oral/sublingual replacement therapy, it is administered daily, while intramuscular administration follows weekly and then monthly patterns (or daily/weekly/monthly depending on the protocol and case)

Specifically, attenuated bacteria can be engineered to selectively target tumors, induce cancer cell death, and inhibit tumor angiogenesis

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In addition, in an environment of chronic nitro-oxidative stress, mTOR may be inactivated by oxidation of Cys1483 [449] and AMPK activation [450, 451]