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Metallothioneins, a family of cysteine-rich proteins, also contribute significantly to regulating the availability of metal ions, thereby reducing their participation in oxidative damage and the ferroptosis process in human liver cancer cells (HepG2) [141]

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In hybrids of CD95-resistant cells with sensitive cells and hybrids of overexpressing Bcl-x L cells with sensitive cells, the phenotype of apoptosis resistance was dominant

In addition, glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines 10,11,12 , and specific genetic interference with glutaminase (GLS) inhibits tumor cell growth 13

The residues of the key 6 YGS 8 motif within the GCT fold are located in loop 1, while the unique dimerization loop 2 is flipped away from the enzymes core domain (Nguyen et al., 2020)