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While HMGB1 contributes to the development of hepatic steatosis, it may also lead to the activation of Kupffer cells and the exacerbation of inflammation [227]

Lipid peroxidation is especially important in heart, brain, and nervous system cells

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Given that microsatellite instability and somatic mutations have been identified in the lungs of PAH patients, DNA damage and repair dysregulation are strongly implicated as triggers for PAH progression [42, 43]

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In contrast, the results of qRT-PCR revealed that the expression levels of key genes ( BECN1 , ATG3 , ATG4D , ATG5 , ATG12 , and SQSTM1 ) of the autophagy signal transduction pathway in HuOCSCs overexpressing ATF4 and treated with anisomycin were significantly higher than those in the control group (Figure 6B)