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This transcriptional activation provides sustained protection against oxidative stress by increasing cellular antioxidant enzyme capacity

The reaction was initiated by the addition of 190 l reaction buffer, adjusted to pH 7.4 by titration with K 2 HPO 4 (40 mM) and KH 2 PO 4 (10 mM) stock solutions, supplemented with NADH (100 M) and sodium pyruvate (600 M)

For analysis of cellular uptake of NP4, the 3D spheroids were treated with Cy5.5-labeled NP4 for 12 h

Drugs 81 , 875879 (2021)

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Singh S, Bedoy A, Muftuoglu M, Li L, Okeleji O, Dipmoy N, Ostermann L, Veletic I, Pacheco C, Basyal M, Kim T, Garland KM, Angel M, Luther S, Rohde C, Andreeff M , Anand V