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2010;20(s2):S293310

Rabani, K

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While GLP-1 analogs for treatment of type 2 diabetes cause mild-to-moderate nausea and vomiting in a significant proportion of patients, their benefits in terms of weight loss and improved glycemic control have allowed the class to overcome these tolerability concerns and become one of the most-prescribed classes of type 2 diabetes medications in the US and Europe (326)

These medications enhance effects of the neurotransmitter gamma-aminobutyric acid (GABA)one of the main inhibitory neurotransmitters in the brainby binding to multiple brain receptor sites

Grx2 is activated by the burst of O 2 production which subsequently deglutathionylates and reactivates Complex I (Figure 3)