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This causes an increase in the production of additional inflammatory cytokines, which in turn causes the inflammatory responses to become more intense (Kelley et al

Hedges' g effect values of 0.20, 0.50 and 0.80 respectively represent small, medium and large effects ( Meta-analysis was performed using R Studio's Metafor package ( I 2 statistics for quantification and Cochran's Q for statistical significance test to evaluate heterogeneity

Moreover, owing to its critical role in maintaining cellular function, targeting mitochondria can be a promising new strategy for HCC treatment

The mice were maintained and treated in accordance with the Association for Research in Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Vision Research

Moreover, surface-bound plasmin may counteract complement as demonstrated for diverse human pathogenic bacteria 8,49,62,63

Induction of MAFLD model High-fat, high fructose diet (HFFD) : MAFLD was induced using fat diet containing 45% fat in the basal diet and 20% fructose in drinking water (prepared by dissolving fructose (20 g / 100 mL of tap water) following previously established protocols 16,17 Experimental groups o Group I (Control) : Rats were fed a standard diet for twelve weeks