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The six-transmembrane epithelial antigen of prostate family member 3 (STEAP3), a metal reductase, reduces Fe 3+ to Fe 2+ in the endosome, ultimately releasing free iron into the cytosol

Circ Res 90:966973 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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FIGURE 1 2.1.1 Iron chelators Deferoxamine (DFO) has been approved by the Food and Drug Administration (FDA) for subcutaneous injection to mitigate elastin-induced ferroptosis in an in vitro ferroptosis model ( DFO inhibits ferroptosis by chelating free intracellular Fe 3+ , down-regulating ROS, and up-regulating intracellular levels of GPX4, the ferritin heavy chain (FTH1), and Cystine/glutamic acid reverse transporter (System Xc-) (Zhang et al., 2020