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Drug repurposing: far beyond new targets for old drugs

Indeed, agricultural fungicides based on dihydroorotate dehydrogenase inhibition are already proceeding to use and could generate olorofim-resistant A

In mammals, circulating inorganic phosphate and polyP (complexes with Ca 2+ ) serve to support extracellular mineralization, which appears to furthermore depend on the concerted expression of collagen type 1 and tissue-non-specific alkaline phosphatase (Murshed et al., 2005)

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2) At the end of Phase 2, 80% of the children were still excreting high amounts of lead and other toxic metals

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