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The fairest one-line summary is that DSIP appears to have real biological activity but a weak and inconsistent clinical efficacy signal

infusion of Ang II in dogs at rates chosen to increase renal arterial concentration by only 1015 pg ml, a level that is still within the physiological concentrations of Ang II, markedly reduced sodium excretion, 40 indicating that physiological levels of Ang II are capable of inducing antinatriuretic effects

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These drugs, like semaglutide and tirzepatide, have been rigorously tested over years of clinical human trials and have been FDA approved to treat obesity