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ADH1A, ADH1B, and ADH1C) to acetaldehyde and then metabolize acetaldehyde primarily by NAD 2 -dependent aldehyde dehydrogenase 2 (ALDH2) to acetic acid

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B12 helps convert homocysteine to methionine

The NIH Office of Dietary Supplements has established no Tolerable Upper Intake Level (UL), meaning these high label doses do not pose the safety risks their large numbers might suggest