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On the other hand, a considerable although short-lasting increase in intraocular pressure may trigger or contribute to the major noxious process seen to progress with the L-NAME retrobulbar application and the supposed failure of NO-system adaptive capabilities [13]

World Journal of Gastroenterology , 10 (7), 1032.

Experimental data demonstrates upregulation of 3-adrenergic receptor expression and restoration of lipolytic responsiveness in systems where this pathway is suppressed