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Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

Preclinical Metabolic Models: Cell and animal research has investigated NNMT inhibition in relation to adipocyte biology, cellular energy expenditure and metabolic signaling

So, without these vitamins, enzymes remain inactive and cannot catalyze specific methylation reactions for the synthesis, activation, or degradation of hormones

Testing is conducted by independent third-party laboratories including Janoshik

van de Donk N, Richardson PG, Malavasi F

It is important to note that while B vitamins have well-established roles in the body, claims regarding specific health benefits should be supported by scientific evidence