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[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Alawsi T, Mattia GP, Al-Bawi Z and Beraldi R, Sens

10.3390/gels9070516 186 NowakA.DuchnikW.MakuchE.Kucharski.Ossowicz-RupniewskaP.CybulskaK.et al (2021)

Hijacking the supplies: metabolism as a novel facet of virus-host interaction

This suggests that the critical Ca 2+ required for PAD4 activation and NETosis may arise from alternative mechanisms, such as lipid scrambling mediated by XKR8

Here, we will (a) examine approaches to elucidate the GCN2methionineROS circuit to determine what forms of therapeutic modulation for T cell immunotherapies may be beneficial in a given context, and (b) explore different nodes within the GCN2-methionine-ROS circuit where intervention may be advantageous