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Following log normalization, the count data were scaled while regressing out mitochondrial reads and principal component analysis (PCA) was performed based on the 2,000 most variable features

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However, exceeding the dosage may cause nausea, abdominal cramps, a fishy body odour, and diarrhoea in some individuals

Fluvastatin and lovastatin target the cholesterol pathway that plays a role in the prenylation of members of the PI3K/AKT/mTOR pathway and RAS, which could impact on the ability of RAS to activate BRAF [67], eventually causing a proliferation arrest

On the other hand, 22 metabolic pathways were significantly downregulated in GDH3 -deleted cells cultured in MM medium and only oxidative phosphorylation, sulphur metabolism, biotin metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis were upregulated