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Integration of TEs either through cut-and-paste or retrotransposition can happen either inside genes (affecting the sequence of the gene) or in the vicinity of genes (which can lead to abnormal activation or repression of the neighboring genes) [59]

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For instance, excessive vitamin D might cause calcium imbalances, while too much folic acid may have unknown long-term effects

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High-risk individuals, such as those with chronic alcoholism, preexisting liver disease, or elevated liver enzymes, warrant particular attention, as they may develop toxicity at lower doses